Peptide-targeted polymer cancerostatics

0463656 - ÚMCH 2017 RIV CZ eng J - Článek v odborném periodiku
Böhmová, Eliška - Pola, Robert
Peptide-targeted polymer cancerostatics.
Physiological Research. Roč. 65, Suppl. 2 (2016), S153-S164. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA MŠMT(CZ) LO1507
Institucionální podpora: RVO:61389013
Klíčová slova: HPMA copolymers * tumor targeting * peptides
Kód oboru RIV: CD - Makromolekulární chemie
Impakt faktor: 1.461, rok: 2016
http://www.biomed.cas.cz/physiolres/pdf/65%20Suppl%202/65_S153.pdf

A tumor-targeting drug delivery system consists of a tumor recognition moiety and a directly linked cytotoxic agent or an agent attached to a water-soluble synthetic polymer carrier through a suitable linker. Conjugation of a drug with a polymer carrier can change its solubility, toxicity, biodistribution, blood clearance and therapeutic specificity. Increased therapeutic specificity of a polymer drug can be achieved by the attachment of a targeting moiety (e.g. a lectin, protein, antibody, or peptide) that specifically interacts with receptors on the target cells. A large number of tumor-specific peptides were described in recent years. After a short introduction, some important examples of peptide-targeted conjugates will be described and discussed.
Trvalý link: http://hdl.handle.net/11104/0264457