Capillary isotachophoresis with ESI-MS detection: Ultrahighly sensitve analysis of diclofenac and ibuprofen in waters

0449442 - ÚIACH 2016 RIV CZ eng C - Konferenční příspěvek (zahraniční konf.)
Malá, Zdeňka - Gebauer, Petr - Boček, Petr
Capillary isotachophoresis with ESI-MS detection: Ultrahighly sensitve analysis of diclofenac and ibuprofen in waters.
CECE 2015. 12th International Interdisciplinary Meeting on Bioanalysis. Brno: Ústav analytické chemie AV ČR, v. v. i, 2015 - (Foret, F.; Křenková, J.; Drobníková, I.; Klepárník, K.), s. 148-150. ISBN 978-80-904959-3-7.
[CECE 2015. International Interdisciplinary Meeting on Bioanalysis /12./. Brno (CZ), 21.09.2015-23.09.2015]
Grant CEP: GA ČR(CZ) GA13-05762S
Institucionální podpora: RVO:68081715
Klíčová slova: CE-MS * HPLC-MS * ITP-MS * ITP-ESI-MS
Kód oboru RIV: CB - Analytická chemie, separace
http://www.ce-ce.org/CECE2015/CECE%202015%20proceedings_full.pdf

This work shows that CE-MS can reach same sensitivity as HPLC-MS, when it is peformed in the ITP-MS mode. By combination of ITP-ESI-MS with an offline SPE preconcentration step and optimization of MS signal collection, LODs below 2x10-12 M can be reached, corresponding to of 0.6 ng/L of diclofenac (Dic) and 0.4 ng/L of ibuprofen (Ibu), compatible to that of SPE-HPLC-MS.
Trvalý link: http://hdl.handle.net/11104/0250988