Activation of p53 pathway by Nutlin-3a inhibits the expression of the therapeutic target alpha 5 integrin in colon cancer cells

0395456 - FGÚ 2014 RIV NL eng J - Článek v odborném periodiku
Janoušková, Hana - Ray, A.M. - Noulet, F. - Lelong-Rebel, I. - Choulier, L. - Schaffner, F. - Lehmann, M. - Martin, S. - Teisinger, Jan - Dontenwill, M.
Activation of p53 pathway by Nutlin-3a inhibits the expression of the therapeutic target alpha 5 integrin in colon cancer cells.
Cancer letters. Roč. 336, č. 2 (2013), s. 307-318. ISSN 0304-3835. E-ISSN 1872-7980
Institucionální podpora: RVO:67985823
Klíčová slova: colon cancer * integrin alpha 5 beta 1 * p53 * Nutlin-3a
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 5.016, rok: 2013

Integrins emerge nowadays as crucial actors of tumor aggressiveness and resistance to therapies. Integrin alpha 5 beta 1, the fibronectin receptor, determines malignant properties of colon carcinoma which is one of the most important causes of cancer-related deaths in the world. Results emphasize the crucial role of alpha 5 beta 1 integrin in colon tumors. Data also suggest that interfering with the integrin alpha 5 beta 1 through the reactivation of p53 by Nutlin-3a may be of valuable interest as a new therapeutic option for colon tumors expressing high level of the integrin and a wild type p53
Trvalý link: http://hdl.handle.net/11104/0223499