Irradiated stem cells and ageing of the haematopoietic system

0390349 - BFÚ 2013 RIV US eng J - Článek v odborném periodiku
Vávrová, J. - Šinkorová, Z. - Řezáčová, M. - Tichý, Adam - Filip, S. - Mokrý, J. - Lukášová, Emilie
Irradiated stem cells and ageing of the haematopoietic system.
Radiation and Environmental Biophysics. Roč. 51, č. 2 (2012), s. 205-213. ISSN 0301-634X. E-ISSN 1432-2099
Výzkumný záměr: CEZ:AV0Z50040702
Institucionální podpora: RVO:68081707
Klíčová slova: Irradiation * Ageing of haematopoiesis * Anaemia
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 1.754, rok: 2012

In the work presented here, changes in haematopoiesis of mice (B6129SF2/J) were studied 1 year after their whole-body exposure to a dose of 7 Gy (72% of mice survived). The irradiated mice were compared with non-irradiated younger (4 months of age) and older (16 months of age) mice. There was a significant increase in the relative abundance of primitive stem cells with long-term capability of the haematopoiesis recovery lin(-)/Sca-1(+)/CD117(+)/CD34(-) in the bone marrow of mice aged 16 months (irradiated and non-irradiated) compared with those aged 4 months. In terms of the ability to respond to further whole-body irradiation at a dose of 1 Gy, the presence of gamma H2A.X foci was studied in lin(-) bone marrow cells.
Trvalý link: http://hdl.handle.net/11104/0219268