Počet záznamů: 1
Benzo[a]pyrene and tumor necrosis factor-alpha coordinately increase genotoxic damage and the production of proinflammatory mediators in alveolar epithelial type II cells
- 1.0366512 - BFÚ 2012 RIV IE eng J - Článek v odborném periodiku
Umannová, Lenka - Machala, M. - Topinka, Jan - Schmuczerová, Jana - Krčmář, P. - Neča, J. - Šujanová, Klára - Kozubík, Alois - Vondráček, Jan
Benzo[a]pyrene and tumor necrosis factor-alpha coordinately increase genotoxic damage and the production of proinflammatory mediators in alveolar epithelial type II cells.
Toxicology Letters. Roč. 206, č. 2 (2011), s. 121-129. ISSN 0378-4274. E-ISSN 1879-3169
Grant CEP: GA ČR(CZ) GAP503/11/1227
Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702; CEZ:AV0Z50390512; CEZ:AV0Z50390703
Klíčová slova: DNA adducts * proinflammatory cytokines * COX-2
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 3.230, rok: 2011
In the present study, we report data showing that a proinflammatory cytokine and environmentally-relevant polycyclic aromatic hydrocarbon interact to potentiate both DNA damage and the inflammatory response in alveolar epithelial type II cells, which may occur through coordinated upregulation of p38 MAP kinase activity.
Trvalý link: http://hdl.handle.net/11104/0201482
Počet záznamů: 1