Facilitation of glutamate and GABA release by P2X receptor activation in supraoptic neurons from freshly isolated rat brain slices

0364772 - FGÚ 2012 RIV GB eng J - Článek v odborném periodiku
Vávra, Vojtěch - Bhattacharya, Anirban - Zemková, Hana
Facilitation of glutamate and GABA release by P2X receptor activation in supraoptic neurons from freshly isolated rat brain slices.
Neuroscience. Roč. 188, - (2011), s. 1-12. ISSN 0306-4522. E-ISSN 1873-7544
Grant CEP: GA AV ČR(CZ) IAA500110910; GA ČR(CZ) GA305/07/0681; GA ČR(CZ) GD305/08/H037; GA MŠMT(CZ) LC554
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: ATP * purinergic P2X receptors * GABA * glutamate * supraoptic nucleus * patch clamp
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 3.380, rok: 2011

The supraoptic nuclei (SON) of the hypothalamus receive an excitatory input that uses ATP as neurotransmitter. Voltage clamp recordings from neurons in rat hypothalamic slices showed that presynaptic ATP-stimulated P2X2 and P2X4 receptors modulate glutamate and GABA release and control the electrical excitability of SON neurons
Trvalý link: http://hdl.handle.net/11104/0200161