Počet záznamů: 1
Peroxisome proliferator-activated receptor-gamma stimulates 11beta-hydroxysteroid dehydrogenase type 1 in rat vascular smooth muscle cells
- 1.0364720 - FGÚ 2012 RIV US eng J - Článek v odborném periodiku
Vagnerová, Karla - Loukotová, Jana - Ergang, Peter - Musílková, Jana - Mikšík, Ivan - Pácha, Jiří
Peroxisome proliferator-activated receptor-gamma stimulates 11beta-hydroxysteroid dehydrogenase type 1 in rat vascular smooth muscle cells.
Steroids. Roč. 76, č. 6 (2011), s. 577-581. ISSN 0039-128X. E-ISSN 1878-5867
Grant CEP: GA ČR(CZ) GAP303/10/0969
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: 11beta-hydroxysteroid dehydrogenase * thiazolidinediones
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 2.829, rok: 2011
The study demonstrates that activation of PPARgamma in vascular smooth muscle cells up-regulates vascular 11HSD1and thus reactivates 11-oxo metabolites to biologically active glucocorticoids. The data provide one of the possible explanations for PPARgamma-agonist’s effects on the cardiovascular system
Trvalý link: http://hdl.handle.net/11104/0200126
Počet záznamů: 1