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Optimization of catalyst-solvent system for preparation of alpha-5,6-dihydro-5-aza-2'-deoxy-[6-3H]-cytidine

  1. 1.
    0363304 - ÚOCHB 2012 GB eng A - Abstrakt
    Elbert, Tomáš
    Optimization of catalyst-solvent system for preparation of alpha-5,6-dihydro-5-aza-2'-deoxy-[6-3H]-cytidine.
    Journal of Labelled Compounds and Radiopharmaceuticals. Roč. 54, č. 5 (2011), s. 285-285. ISSN 0362-4803.
    [Workshop of the International Isotope Society - Central European Division. The Synthesis and Applications of Isotopes and Isotopically Labelled Compounds /17./. 23.09.2010-24.09.2010, Bad Soden]
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: tritium * labelled compounds * alfa-5,6-dihydro-5-aza-2'-deoxy-cytidine
    Kód oboru RIV: CC - Organická chemie

    The optimization of catalyst-solvent system for the tritiation of alfa-5-aza-2'-deoxy-cytidine was targeted on the shortening of the reaction time and on the suppression of the exchange solution – gas. The combination of Adams catalyst (platinum dioxide) and dimethylformamide gave better than 90% conversion in 75 minutes and about 50% enrichment by deuterium in model experiments.
    Trvalý link: http://hdl.handle.net/11104/0199283
Počet záznamů: 1