The antifungal effect of peptides from hymenoptera venom and their analogs

0360967 - ÚOCHB 2012 RIV PL eng J - Článek v odborném periodiku
Slaninová, Jiřina - Putnová, Helena - Borovičková, Lenka - Šácha, Pavel - Čeřovský, Václav - Monincová, Lenka - Fučík, Vladimír
The antifungal effect of peptides from hymenoptera venom and their analogs.
Central European Journal of Biology. Roč. 6, č. 2 (2011), s. 150-159. ISSN 1895-104X
Grant CEP: GA ČR GA203/08/0536
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: antifungal agents * candida * fluorescent microscopy * rhodamine 6G * fluorescein-labeled peptide
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 1.000, rok: 2011

Minimal inhibitory concentrations (MICs) against different Candida species (C. albicans, C. krusei, C. glabrata, C. tropicalis and C. parapsilosis) of recently isolated, synthesized and characterized antimicrobial alpha-helical amphipathic peptides (12–18 amino acids long) from the venom of hymenoptera (melectin, lasioglossins I, II, and III, halictines I and II) as well as a whole series of synthetic analogs were determined. In the case of the natural peptides they amounted to 4–20 .mu.M (7–40 mg/l). The most active ones were the synthetic analogs all-D-lasioglossin III and KNWKK-Aib-LGK-Aib-IK-Aib-VK-NH2.
Trvalý link: http://hdl.handle.net/11104/0198398