Negative regulation of Toll-like receptor signaling plays an essential role in homeostasis of the intestine

0360867 - MBÚ 2012 RIV DE eng J - Článek v odborném periodiku
Biswas, A. - Wilmanski, J. - Forsman, H. - Hrnčíř, Tomáš - Hao, L. - Tlaskalová-Hogenová, Helena - Kobayashi, K.
Negative regulation of Toll-like receptor signaling plays an essential role in homeostasis of the intestine.
European Journal of Immunology. Roč. 41, č. 1 (2011), s. 182-194. ISSN 0014-2980. E-ISSN 1521-4141
Grant CEP: GA ČR GP310/09/P182
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: Caspase-1 * Colitis * IL-10
Kód oboru RIV: EC - Imunologie
Impakt faktor: 5.103, rok: 2011

A healthy intestinal tract is characterized by controlled homeostasis due to the balanced interaction between commensal bacteria and the host mucosal immune system. Human and animal model studies have supported the hypothesis that breakdown of this homeostasis may underlie the pathogenesis of inflammatory bowel diseases. However, it is not well understood how intestinal microflora stimulate the intestinal mucosal immune system and how such activation is regulated
Trvalý link: http://hdl.handle.net/11104/0198322