Glycosidases in Carbohydrate Synthesis: When Organic Chemistry Falls Short

0360713 - MBÚ 2012 RIV CH eng J - Článek v odborném periodiku
Bojarová, Pavla - Křen, Vladimír
Glycosidases in Carbohydrate Synthesis: When Organic Chemistry Falls Short.
Chimia. Roč. 65, 1-2 (2011), 64-70. ISSN 0009-4293. E-ISSN 0009-4293
Grant CEP: GA ČR GP203/09/P024; GA MŠMT(CZ) LC06010; GA MŠMT OC09045
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: Carbohydrate * Enzymatic synthesis * Glycosidase
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 1.212, rok: 2011

Thanks to the stability, good availability, stereoselectivity and broad substrate specificity, oligosacharide synthesis catalyzed by glycosidases represents an elegant way to komplex carbohydrate structures. Two approaches to glycosidase catalysis are presented: i) the use of structurally modified substrates that carry various functional moieties in the molecule, and ii) the design of mutant glycosidases void of hydrolytic activity. Products of glycosidase catalyzed synthesis are applicable in a range of areas such as immunology, therapy of Alzheimer’s or Parkinson’s diseases and the synthesis of neoglycoproteins
Trvalý link: http://hdl.handle.net/11104/0198199