Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway

0357770 - BFÚ 2011 RIV GB eng J - Článek v odborném periodiku
Vondálová Blanářová, Olga - Jelínková, Iva - Szoor, A. - Skender, Belma - Souček, Karel - Horváth, Viktor - Vaculová, Alena - Anděra, Ladislav - Sova, P. - Szollosi, J. - Hofmanová, Jiřina - Vereb, G. - Kozubík, Alois
Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway.
Carcinogenesis. Roč. 32, č. 1 (2011), s. 42-51. ISSN 0143-3334. E-ISSN 1460-2180
Grant CEP: GA ČR(CZ) GA301/07/1557; GA MZd NS9600
Grant ostatní: GA ČR(CZ) GD303/09/H048
Program: GD
Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702; CEZ:AV0Z50520514
Klíčová slova: TRAIL * platinum complexes * apoptosis
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 5.702, rok: 2011

Platinum complexes LA-12 and cisplatin enhanced TRAIL-induced apoptosis in colon and prostate cancer cells. They increased surface expression of DR5 receptor for TRAIL, which has been shown to be crucial for induction of apoptosis. Moreover, LA-12 and cisplatin mediated translocation of TRAIL receptors DR4 and DR5 to lipid rafts and enhanced internalization of TRAIL. These events modulated early steps of TRAIL, signaling and may contribute to induction of apoptosis.
Trvalý link: http://hdl.handle.net/11104/0195967