Graft survival and cytokine production profile after limbal transplantation in the experimental mouse model

0355310 - ÚMG 2012 RIV GB eng J - Článek v odborném periodiku
Lenčová, Anna - Pokorná, Kateřina - Zajícová, Alena - Krulová, Magdalena - Filipec, M. - Holáň, Vladimír
Graft survival and cytokine production profile after limbal transplantation in the experimental mouse model.
Transplant Immunology. Roč. 24, č. 3 (2011), s. 189-194. ISSN 0966-3274. E-ISSN 1878-5492
Grant CEP: GA AV ČR KAN200520804; GA MŠMT 1M0506; GA ČR GD310/08/H077
Výzkumný záměr: CEZ:AV0Z50520514
Klíčová slova: limbal transplantation * graft survival * cytokine response
Kód oboru RIV: EC - Imunologie
Impakt faktor: 1.459, rok: 2011

A new model of orthotopic limbal transplantation was established in the mouse. The survival of limbal autografts, allografts and xenografts was characterized according to the clinical criteria, and intragraft cytokine response was determined by a real-time PCR. The results showed that the limbal grafts do not enjoy immune privilege of the eye and are promptly rejected by Th1 or combined Th1 and Th2 type of immune response involving CD4 pozitive cells and iNOS expression. Targeting this pathway may be an effective way to prevent and treat limbal graft rejection.
Trvalý link: http://hdl.handle.net/11104/0194115