Počet záznamů: 1
Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2
- 1.0351205 - BFÚ 2011 RIV US eng J - Článek v odborném periodiku
Witte, F. - Bernatík, O. - Kirchner, K. - Mašek, J. - Mahl, A. - Krejčí, P. - Mundlos, S. - Schambony, A. - Bryja, Vítězslav - Stricker, S.
Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2.
FASEB Journal. Roč. 24, č. 7 (2010), s. 2417-2426. ISSN 0892-6638. E-ISSN 1530-6860
Grant CEP: GA ČR(CZ) GC204/09/J030
Grant ostatní: GA AV ČR(CZ) KJB501630801; GA ČR(CZ) GD204/09/H058; GA ČR(CZ) GA204/09/0498
Program: GD
Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Klíčová slova: Wnt/beta-catenin signaling * casein kinase * Ror2
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 6.515, rok: 2010
Dishevelled (Dvl) is a multifunctional effector of different Wnt cascades. We provide evidence that Dvl phosphorylated by casein kinase 1 epsilon can bind atypical receptor kinase Ror2. We show that CK1-phosphorylated Dvl induced by both canonical and non-canonical Wnt ligands triggers negative feedback regulation in a Ror2-dependent manner.
Trvalý link: http://hdl.handle.net/11104/0191007
Počet záznamů: 1