Immunogenicity and immunomodulatory properties of HPMA-based polymers

0350356 - MBÚ 2011 RIV NL eng J - Článek v odborném periodiku
Říhová, Blanka - Kovář, Marek
Immunogenicity and immunomodulatory properties of HPMA-based polymers.
Advanced Drug Delivery Reviews. Roč. 62, č. 2 (2010), s. 184-191. ISSN 0169-409X. E-ISSN 1872-8294
Grant CEP: GA AV ČR KAN200200651; GA AV ČR IAAX00500803; GA AV ČR IAA500200712; GA MŠMT 1M0505
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: Immunogenicity * Hpma * Immunomodulation
Kód oboru RIV: EE - Mikrobiologie, virologie
Impakt faktor: 13.577, rok: 2010

In this study it was shown both in mice and humans that HPMA copolymer-bound doxorubicin (DOX-HPMA) conjugates possess besides powerfull anti-tumor effect also various immunomodulatory properties and exert significantly decreased side-toxicities, minimized bone marrow toxicity and cardiotoxicity being the most important ones. The possibility to induce potent and long-lasting tumor-specific immunity during the tratment with these compounds which is capable to provide protection against minimal residual disease is one of the most important and therapeutically valuable features of these conjugates
Trvalý link: http://hdl.handle.net/11104/0006133