CycloSal-Phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-Deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases

0350071 - ÚOCHB 2011 RIV DE eng J - Článek v odborném periodiku
Spáčilová, Pavla - Nauš, Petr - Pohl, Radek - Votruba, Ivan - Snášel, Jan - Zábranská, Helena - Pichová, Iva - Ameral, R. - Birkuš, G. - Cihlař, T. - Hocek, Michal
CycloSal-Phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-Deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases.
ChemMedChem. Roč. 5, č. 8 (2010), s. 1386-1396. ISSN 1860-7179. E-ISSN 1860-7187
Grant CEP: GA MŠMT 1M0508
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: nucleosides * pronucleotides * deazapurines * cytostatics
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 3.306, rok: 2010

A series of cycloSal-phosphate prodrugs of a recently described new class of nucleoside cytostatics (6-hetaryl-7-deazapurine ribonucleosides) was prepared. The in vitro cytostatic effect of the pronucleotides was compared with parent nucleoside analogues. In most cases, the activity of the pronucleotide was similar to or somewhat lower than that of the corresponding parent nucleosides.
Trvalý link: http://hdl.handle.net/11104/0190164