Počet záznamů: 1
Cytotoxicity, cellular uptake, glutathione and DNA interactions of an antitumor large-ring PtII chelate complex incorporating the cis-1,4-diaminocyclohexane carrier ligand
- 1.0347184 - BFÚ 2011 RIV US eng J - Článek v odborném periodiku
Kašpárková, Jana - Suchánková, T. - Halámiková, Anna - Zerzánková, Lenka - Vrána, Oldřich - Margiotta, N. - Natile, G. - Brabec, Viktor
Cytotoxicity, cellular uptake, glutathione and DNA interactions of an antitumor large-ring PtII chelate complex incorporating the cis-1,4-diaminocyclohexane carrier ligand.
Biochemical Pharmacology. Roč. 79, č. 4 (2010), s. 552-564. ISSN 0006-2952. E-ISSN 1873-2968
Grant CEP: GA MŠMT(CZ) LC06030; GA MŠMT(CZ) ME08017; GA MŠMT(CZ) OC08003; GA AV ČR(CZ) 1QS500040581; GA AV ČR(CZ) KAN200200651; GA AV ČR(CZ) IAA400040803; GA AV ČR(CZ) GD301/09/H004
Grant ostatní: GA MŠk(CZ) OC09018
Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Klíčová slova: DNA * platinum * cancer
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 4.889, rok: 2010
This work describes a mechanistic study aimed at finding differences in those features of mechansim of activity of new antitumor PtII complex [PtCl2(cis-1,4-DACH)] (DACH = diaminocyclohexane) which are associated with its different biological effects in comparison with conventional cisplatin.
Trvalý link: http://hdl.handle.net/11104/0188017
Počet záznamů: 1