Immunoregulatory properties of mouse limbal stem cells

0346785 - ÚMG 2011 RIV US eng J - Článek v odborném periodiku
Holáň, Vladimír - Pokorná, Kateřina - Procházková, Jana - Krulová, M. - Zajícová, Alena
Immunoregulatory properties of mouse limbal stem cells.
Journal of Immunology. Roč. 184, č. 4 (2010), s. 2124-2129. ISSN 0022-1767. E-ISSN 1550-6606
Grant CEP: GA AV ČR KAN200520804; GA MŠMT 1M0506; GA ČR GD310/08/H077
Výzkumný záměr: CEZ:AV0Z50520514
Klíčová slova: Limbal stem cells * immunoregulation * apoptosis
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 5.745, rok: 2010

We isolated a highly purified population of mouse limbal stem cells. These cells expressed immunosuppressive and immunoregulatory properties. In addition, limbal stem cells had a high expression of genes for the anti-apoptotic molecules Bcl-1, XIAP and Survivin and for Fas ligand, and displayed an enhanced resistence to the apoptosis-inducing agents and to cell-mediated immunity. The results thus showed novel undescribed properties of adult stem cells. These immunoregulatory and self-protecting properties of adult tissue specific stem cells can be responsible for protection of stem cells which have a vital role in reparation and regeneration of tissues and organs.
Trvalý link: http://hdl.handle.net/11104/0187714