The difference in effect of mGlu2/3 and mGlu5 receptor agonists on cognitive impairment induced by MK-801

0344048 - FGÚ 2011 RIV NL eng J - Článek v odborném periodiku
Valeš, Karel - Svoboda, Jan - Benkovičová, Kristína - Bubeníková-Valešová, V. - Stuchlík, Aleš
The difference in effect of mGlu2/3 and mGlu5 receptor agonists on cognitive impairment induced by MK-801.
European Journal of Pharmacology. Roč. 639, 1-3 (2010), s. 91-98. ISSN 0014-2999. E-ISSN 1879-0712
Grant CEP: GA MZd(CZ) NR9178
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: animal model of schizophrenia * metabotropic glutamate receptor * cognition
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 2.737, rok: 2010

The manipulation of glutamate neurotransmission could represent a potential strategy for the pharmacotherapy of schizophrenic symptoms. In our study we evaluated the effect of agonists and allosteric modulators of mGluR2/3 and mGluR5 on performance in a cognitive task in animal model of schizophrenia like behavior. The results show that application of the mGlu2/3 receptor agonist had no effect on cognitive impairment. However, the mGlu5 receptor agonists ameliorated cognitive impairment without affecting locomotion
Trvalý link: http://hdl.handle.net/11104/0186367