High efficiency of ROS production by glycerophosphate dehydrogenase in mammalian mitochondria

0338638 - FGÚ 2010 RIV US eng J - Článek v odborném periodiku
Mráček, Tomáš - Pecinová, Alena - Vrbacký, Marek - Drahota, Zdeněk - Houštěk, Josef
High efficiency of ROS production by glycerophosphate dehydrogenase in mammalian mitochondria.
Archives of Biochemistry and Biophysics. Roč. 481, č. 1 (2009), s. 30-36. ISSN 0003-9861. E-ISSN 1096-0384
Grant CEP: GA MŠMT(CZ) 1M0520; GA ČR(CZ) GA303/06/1261
Grant ostatní: EC(XE) LSHM-CT-2004-503116
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: mGPDH * ROS * mitochondria
Kód oboru RIV: CE - Biochemie
Impakt faktor: 3.046, rok: 2009

A high rates of mGPDH-dependent ROS production were observed in liver, heart and brain mitochondria treated with antimycin. When related to activity of mGPDH, 3-39-fold higher ROS production was found in contrast to succinate dehydrogenase- or NADH dehydrogenase-dependent ROS production. It was also 22-66 higher compared to that in BAT. Our results demonstrate high efficiency of mGPDH-dependent ROS production localized to the dehydrogenase + CoQ and complex III, in mammalian mitochondria with a low content of mGPDH and suggest its endogenous inhibition in BAT
Trvalý link: http://hdl.handle.net/11104/0182362