Mechanism of formation of (deoxy)guanosine adducts derived from peroxidase-catalyzed oxidation of the carcinogenic nonaminoazo dye 1-phenylazo-2-hydroxynaphthalene (Sudan I)

0332891 - ÚOCHB 2010 RIV US eng J - Článek v odborném periodiku
Dračínský, Martin - Cvačka, Josef - Semanská, M. - Martínek, V. - Frei, E. - Stiborová, M.
Mechanism of formation of (deoxy)guanosine adducts derived from peroxidase-catalyzed oxidation of the carcinogenic nonaminoazo dye 1-phenylazo-2-hydroxynaphthalene (Sudan I).
Chemical Research in Toxicology. Roč. 22, č. 11 (2009), s. 1765-1773. ISSN 0893-228X. E-ISSN 1520-5010
Grant CEP: GA AV ČR KJB400550903
Grant ostatní: GA ČR(CZ) GA303/09/0472; GA ČR(CZ) GA203/09/0812
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: Sudan I * peroxidase * NMR spectroscopy * (deoxy)guanosin adducts
Kód oboru RIV: CE - Biochemie
Impakt faktor: 3.740, rok: 2009

We investigated peroxidase-mediated oxidation of and (deoxy)guanosine adduct formation by 1-phenylazo-2-hydroxynaphthalene (Sudan I), a liver and urinary bladder carcinogen for rodents. Using TLC and/or HPLC combined with mass and/or NMR spectrometry, we characterized the structures of two major peroxidase-mediated Sudan I metabolites and those of adducts of (deoxy)guanosine that are formed during Sudan I oxidation.
Trvalý link: http://hdl.handle.net/11104/0178011