Sensitivity and specificity of the bioassay of estrogenicity in mammary gland and seminal vesicles of male mice

0213391 - UZFG-Y 20023002 RIV CZ eng J - Článek v odborném periodiku
Škarda, Josef
Sensitivity and specificity of the bioassay of estrogenicity in mammary gland and seminal vesicles of male mice.
Physiological Research. Roč. 51, č. 3 (2002), s. 267-276. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA ČR GA523/99/0843; GA AV ČR KSK5020115
Klíčová slova: bioassay * estrogenicity * mammary gland
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 0.984, rok: 2002

The effects of a combination of estradiol plus progesterone in the mammary gland were mimicked by norethindrone acetate and inhibited by both testosterone and cortisol. Estradiol,progesterone, norethindrone acetate, or testosterone did not affect spleen weight and size of mammary lymph nodes.However, cortisol significantly decreased not only spleen weights but also size of mammary lymph nodes.The results show that simultaneous evaluation of mammary gland growth, seminal vesicles, and spleen weight in the same animal is suitable for bioassay of estrogenicity as well as for detection of androgenic and antiandrogenic activities.
Trvalý link: http://hdl.handle.net/11104/0108929