Coenzyme Q blocks biochemical but not receptor-mediated apoptosis by increasing mitochondrial antioxidant protection

0191286 - UMG-J 20010356 RIV NL eng J - Článek v odborném periodiku
Alleva, R. - Tomasetti, M. - Anděra, Ladislav - Gellert, N. - Borghi, B. - Weber, C. - Murphy, M. P. - Neužil, J.
Coenzyme Q blocks biochemical but not receptor-mediated apoptosis by increasing mitochondrial antioxidant protection.
FEBS Letters. Roč. 503, č. 1 (2001), s. 46-50. ISSN 0014-5793. E-ISSN 1873-3468
Grant CEP: GA ČR GA301/99/0350
Výzkumný záměr: CEZ:AV0Z5052915
Klíčová slova: coenzyme Q * apoptosis
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 3.644, rok: 2001

Generation of free radicals is often associated with the induction of apoptosis. Exposure of Jurkat cells to alpha-tocopheryl succinate (alpha-TOS), hydrogen peroxide (HP), anti-Fas IgM or TRAIL led to apoptosis. The reduced form of coenzyme Q suppressed cell death due to the chemical agents. However, coenzyme did not block apoptosis induced by anti-Fas IgM or TRAIL. Ubiquinol-10 inhibited ROS generation in cells exposed to alpha-TOS, and mitochondrially-targeted coenzyme Q analogue blocked apoptosis induced by alpha-TOS.
Trvalý link: http://hdl.handle.net/11104/0087041