Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3′,3′-c-Di(2′F,2′dAMP)

PIMKOVÁ POLIDAROVÁ, M., BŘEHOVÁ, P., KAISER, M. M., SMOLA, M., DRAČÍNSKÝ, M., SMITH, J., MAREK, A., DEJMEK, M., ŠÁLA, M., GUTTEN, O., RULÍŠEK, L., NOVOTNÁ, B., BRÁZDOVÁ, A., JANEBA, Z., NENCKA, R., BOUŘA, E., PÁV, O., BIRKUŠ, G. Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3′,3′-c-Di(2′F,2′dAMP). Journal of Medicinal Chemistry. 2021, 64(11), 7596-7616. ISSN 0022-2623. E-ISSN 1520-4804. Dostupné z: doi: 10.1021/acs.jmedchem.1c00301.