Myocardial m6A regulators in postnatal development: effect of sex

0565798 - FGÚ 2023 RIV CZ eng J - Článek v odborném periodiku
Semenovykh, Dmytro - Benák, Daniel - Holzerová, Kristýna - Černá, B. - Telenský, P. - Vavříková, Tereza - Kolář, František - Neckář, Jan - Hlaváčková, Markéta
Myocardial m6A regulators in postnatal development: effect of sex.
Physiological Research. Roč. 71, č. 6 (2022), s. 877-882. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA ČR(CZ) GJ19-04790Y
Institucionální podpora: RVO:67985823
Klíčová slova: epitranscriptomics * N6 -methyladenosine * postnatal development * heart
Obor OECD: Physiology (including cytology)
Impakt faktor: 2.1, rok: 2022
Způsob publikování: Open access
https://www.biomed.cas.cz/physiolres/pdf/2022/71_877.pdf

N6-methyladenosine (m6A) is an abundant mRNA modification affecting mRNA stability and protein expression. It is a highly dynamic process, and its outcomes during postnatal heart development are poorly understood. Here we studied m6A machinery in the left ventricular (LV) myocardium of Fisher344 male and female rats (postnatal days one to ninety, P1-P90) using Western Blot. A downward pattern of target protein levels (demethylases FTO and ALKBH5, methyltransferase METTL3, reader YTHDF2) was revealed in male and female rat LVs during postnatal development. On P1, the FTO protein level was significantly higher in male LVs compared to female.
Trvalý link: https://hdl.handle.net/11104/0337288