Multifunctional energy landscape for a DNA G-quadruplex: An evolved molecular switch

0486065 - BFÚ 2018 RIV US eng J - Článek v odborném periodiku
Cragnolini, T. - Chakraborty, D. - Šponer, Jiří - Derreumaux, P. - Pasquali, S. - Wales, D.J.
Multifunctional energy landscape for a DNA G-quadruplex: An evolved molecular switch.
Journal of Chemical Physics. Roč. 147, č. 15 (2017), č. článku 152715. ISSN 0021-9606. E-ISSN 1089-7690
Grant CEP: GA ČR(CZ) GA16-13721S
Institucionální podpora: RVO:68081707
Klíčová slova: telomeric g-quadruplex * gb1 hairpin peptide
Obor OECD: Physical chemistry
Impakt faktor: 2.843, rok: 2017

We explore the energy landscape for a four-fold telomere repeat, obtaining interconversion pathways between six experimentally characterised G-quadruplex topologies. The results reveal a multi-funnel system, with a variety of intermediate configurations and misfolded states. This organisation is identified with the intrinsically multi-functional nature of the system, suggesting a new paradigm for the classification of such biomolecules and clarifying issues regarding apparently conflicting experimental results. Published by AIP Publishing.
Trvalý link: http://hdl.handle.net/11104/0280952