Meet interesting abbreviations in clinical mass spectrometry: from compound classification by REIMS to multimodal and mass spectrometry imaging (MSI)

0479451 - MBÚ 2018 RIV SK eng J - Článek v odborném periodiku
Luptáková, Dominika - Pluháček, Tomáš - Palyzová, Andrea - Přichystal, Jakub - Balogh, J. - Lemr, Karel - Juránek, I. - Havlíček, Vladimír
Meet interesting abbreviations in clinical mass spectrometry: from compound classification by REIMS to multimodal and mass spectrometry imaging (MSI).
Acta virologica. Roč. 61, č. 3 (2017), s. 353-360. ISSN 0001-723X. E-ISSN 1336-2305
Grant CEP: GA MŠMT(CZ) LO1509; GA ČR(CZ) GA16-20229S
Institucionální podpora: RVO:61388971
Klíčová slova: REIMS * multimodal * mass spectrometry imaging
Obor OECD: Microbiology
Impakt faktor: 0.696, rok: 2017

This feature article discusses two modern mass spectrometry abbreviations in their clinical applications. Rapid evaporative ionization mass spectrometry (REIMS) is reported as a molecular classification tool useful for spectral features definition prior to mass spectrometry imaging (MSI). REIMS is appreciated not only as an ionization technique coupled with a surgical device but particularly as a biomarker discovery tool. For more complex understanding of pathological processes at cellular and molecular levels, the importance of multimodal approach in imaging applications is documented in the context of fiducial markers needed for hyperspectral data fusion collected by optical microscopy, elemental and molecular MSI. Finally, pathogen inactivation needed prior to the sectioning of the infected tissue is reported, and the impact of formaldehyde crosslinking to signal reduction is discussed.
Trvalý link: http://hdl.handle.net/11104/0275441