Identification of a hybrid myocardial zone in the mammalian heart after birth

0477526 - FGÚ 2018 RIV GB eng J - Článek v odborném periodiku
Tian, X. - Li, Y. - He, L. - Zhang, H. - Huang, X. - Liu, Q. - Pu, W. - Zhang, LB. - Li, Yi. - Zhao, H. - Wang, Z. - Zhu, J. - Nie, Y. - Hu, S. - Sedmera, David - Zhong, T. P. - Yu, Y. - Zhang, L. - Yan, Y. - Qiao, Z. - Wang, Q-D. - Wu, S. M. - Pu, W. T. - Anderson, R. H. - Zhou, B.
Identification of a hybrid myocardial zone in the mammalian heart after birth.
Nature Communications. Roč. 8, Jul 20 (2017), č. článku 87. E-ISSN 2041-1723
Grant CEP: GA ČR(CZ) GA13-12412S; GA ČR(CZ) GA16-02972S
Institucionální podpora: RVO:67985823
Klíčová slova: left-ventricular noncompaction * lineage tracing * coronary-arteries * cardiomyocyte proliferation * gene-expression
Obor OECD: Anatomy and morphology (plant science to be 1.6)
Impakt faktor: 12.353, rok: 2017

Noncompaction cardiomyopathy is characterized by the presence of extensive trabeculations, which could lead to heart failure and malignant arrhythmias. How trabeculations resolve to form compact myocardium is poorly understood. Elucidation of this process is critical to understanding the pathophysiology of noncompaction disease. Here we use genetic lineage tracing to mark the Nppa(+) or Hey(2+) cardiomyocytes as trabecular and compact components of the ventricular wall. We find that Nppa(+) and Hey(2+) cardiomyocytes, respectively, from the endocardial and epicardial zones of the ventricular wall postnatally. Interposed between these two postnatal layers is a hybrid zone, which is composed of cells derived from both the Nppa(+) and Hey(2+) populations. Inhibition of the fetal Hey(2+) cell contribution to the hybrid zone results in persistence of excessive trabeculations in postnatal heart. Our findings indicate that the expansion of Hey(2+) fetal compact component, and its contribution to the hybrid myocardial zone, are essential for normal formation of the ventricular walls.
Trvalý link: http://hdl.handle.net/11104/0273858