Synthesis, characterization, crystal structures, QSAR study and antibacterial activities of organotin bisphosphoramidates

0462124 - FZÚ 2017 RIV CH eng J - Článek v odborném periodiku
Gholivand, K. - Valmoozi, A.A.E. - Gholami, A. - Dušek, Michal - Eigner, Václav - Abolghasemi, S.
Synthesis, characterization, crystal structures, QSAR study and antibacterial activities of organotin bisphosphoramidates.
Journal of Organometallic Chemistry. Roč. 806, Mar (2016), s. 33-44. ISSN 0022-328X. E-ISSN 1872-8561
Grant CEP: GA ČR GA15-12653S
Institucionální podpora: RVO:68378271
Klíčová slova: bisphosphoramidate * organotin compounds * crystal structure * antibacterial activity * QSAR
Kód oboru RIV: BM - Fyzika pevných látek a magnetismus
Impakt faktor: 2.184, rok: 2016

Organotin complexes of bisphosphoramidates were prepared by the reaction of SnR1R2R3Cl (where R = alkyl/aryl/Cl) and Ph2P(O)XP(O)Ph2 ligands (where X = diamine). All the compounds were characterized by NMR and IR spectroscopy and X-Ray crystallography. The synthesized compounds were screened for the antibacterial activity against B. cereus and E. coli. Triphenyltin adducts exhibited a marked activity only against Gram-positive bacterium B. Cereus. The correlation matrix of QSAR models and docking analysis confirmed the influence of the net charge (QSn) and polarizability of Sn atom of complexes o n the inhibition of B. cereus.
Trvalý link: http://hdl.handle.net/11104/0261842