The Regulatory Role of Nuclear Factor Kappa B in the Heart of Hereditary Hypertriglyceridemic Rat

0459551 - FGÚ 2017 RIV US eng J - Článek v odborném periodiku
Vranková, S. - Barta, A. - Klimentová, J. - Dovinová, I. - Líšková, Silvia - Dobešová, Zdenka - Pecháňová, O. - Kuneš, Jaroslav - Zicha, Josef
The Regulatory Role of Nuclear Factor Kappa B in the Heart of Hereditary Hypertriglyceridemic Rat.
Oxidative Medicine and Cellular Longevity. Roč. 2016, č. 2016 (2016), s. 9814038. ISSN 1942-0900. E-ISSN 1942-0994
Grant CEP: GA MZd(CZ) NV15-25396A
Institucionální podpora: RVO:67985823
Klíčová slova: nuclear factor-kB * nitric oxide * reactive oxygen species * heart * hereditary hypertriglyceridemic rats
Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
Impakt faktor: 4.593, rok: 2016

Activation of nuclear factor-kB by increased production of reactive oxygen species (ROS) might induce expression of different antioxidant enzymes and nitric oxide synthase (NOS) isoforms. NF-kB inhibition in hereditary hypertriglyceridemic rats led to decreased ROS degradation by superoxide dismutase and to increased cardiac oxidative damage and elevated blood pressure. Under these conditions increased NO generation may represent a counterregulatory mechanism activate by ROS.
Trvalý link: http://hdl.handle.net/11104/0259737