Cholesterol and fat lowering with hydrophobic polysaccharide derivatives

0457794 - ÚŽFG 2016 RIV GB eng J - Článek v odborném periodiku
Čopíková, J. - Taubner, T. - Tůma, J. - Synytsya, A. - Dušková, Dagmar - Marounek, Milan
Cholesterol and fat lowering with hydrophobic polysaccharide derivatives.
Carbohydrate Polymers. Roč. 116, č. 1 (2015), s. 207-214. ISSN 0144-8617. E-ISSN 1879-1344
Institucionální podpora: RVO:67985904
Klíčová slova: hydrophobically modified polysaccharides * structure * thermal analysis
Kód oboru RIV: CE - Biochemie
Impakt faktor: 4.219, rok: 2015

Hydrophobic derivatives of highly methylated citrus pectin, chitosan and cellulose were prepared and tested as potential cholesterol lowering agents. Elemental analysis and spectroscopic methods confirmed high substitution degree for all of them. Substitution with long alkyl/acyl groups led to significant changes in physical and thermal properties of modified polysaccharides. Sorption of cholate and cholesterol by these polysaccharide-based sorbents was estimated in comparison with the synthetic drug cholestyramine. It was found that modified polysaccharides have high affinity to cholesterol. By contrast, cholestyramine was effective only in cholate sorption.
Trvalý link: http://hdl.handle.net/11104/0258155