Alkaline Phosphatase in Stem Cells

0457648 - BFÚ 2016 RIV US eng J - Článek v odborném periodiku
Štefková, K. - Procházková, Jiřina - Pachernik, J.
Alkaline Phosphatase in Stem Cells.
Stem Cells International. Roč. 2015, č. 2015 (2015). ISSN 1687-966X. E-ISSN 1687-9678
Institucionální podpora: RVO:68081707
Klíčová slova: PRIMORDIAL GERM-CELLS * P38 MAP KINASE * EMBRYONAL CARCINOMA-CELLS
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 3.687, rok: 2015

Alkaline phosphatase is an enzyme commonly expressed in almost all living organisms. In humans and other mammals, determinations of the expression and activity of alkaline phosphatase have frequently been used for cell determination in developmental studies and/or within clinical trials. Alkaline phosphatase also seems to be one of the key markers in the identification of pluripotent embryonic stem as well as related cells. However, alkaline phosphatases exist in some isoenzymes and isoforms, which have tissue specific expressions and functions. Here, the role of alkaline phosphatase as a stem cell marker is discussed in detail. First, we briefly summarize contemporary knowledge of mammalian alkaline phosphatases in general. Second, we focus on the known facts of its role in and potential significance for the identification of stem cells.
Trvalý link: http://hdl.handle.net/11104/0258044