Susceptibility of rats with altered thyroid status to malignant arrhythmias is primarily related to myocardial levels of connexin-43 and can be partially ameliorated by supplementation with red palm oil

0435701 - FGÚ 2015 RIV CA eng J - Článek v odborném periodiku
Bačová, B. - Vinczenzová, C. - Žurmanová, J. - Kašparová, Dita - Knezl, V. - Radošinská, J. - Beňová, T. - Pavelka, Stanislav - Soukup, Tomáš - Tribulová, N.
Susceptibility of rats with altered thyroid status to malignant arrhythmias is primarily related to myocardial levels of connexin-43 and can be partially ameliorated by supplementation with red palm oil.
Experimental and Clinical Cardiology. Roč. 18, Suppl A (2013), 41A-46A. ISSN 1205-6626
Grant CEP: GA MŠMT(CZ) 7AMB12SK158; GA ČR(CZ) GA305/09/1228; GA ČR(CZ) GAP304/12/0259
Grant ostatní: Univerzita Karlova(CZ) 628412
Výzkumný záměr: CEZ:AV0Z50110509
Institucionální podpora: RVO:67985823
Klíčová slova: thyroid hormones * cardiac arrhythmias * connexin-43 * PKC.epsilon * red palm oil
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 0.758, rok: 2013

We aimed to explore relationship between myocardial electrical coupling protein connexin-43 (Cx43) and susceptibility of rats with altered thyroid status to malignant arrhythmias and to examine possible beneficial effect of red palm oil (RPO). We conclude that there is an inverse relationship between myocardial Cx43 expression and heart susceptibility of rats with altered thyroid status to VF, whereby PKC.epsilon can also be involved. RPO intake increased threshold for induction of VF in the TH rats, apparently again due to up-regulation of Cx43 and PKC.epsilon
Trvalý link: http://hdl.handle.net/11104/0239522