Beneficial effect of human induced pluripotent stem cell-derived neural precursors in spinal cord injury repair

0435646 - ÚEM 2016 RIV US eng J - Článek v odborném periodiku
Romanyuk, Nataliya - Amemori, Takashi - Turnovcová, Karolína - Procházka, Pavel - Onteniente, B. - Syková, Eva - Jendelová, Pavla
Beneficial effect of human induced pluripotent stem cell-derived neural precursors in spinal cord injury repair.
Cell Transplantation. Roč. 24, č. 9 (2015), s. 1781-1797. ISSN 0963-6897. E-ISSN 1555-3892
Grant CEP: GA MŠMT LH12024; GA ČR(CZ) GA13-00939S; GA ČR(CZ) GBP304/12/G069; GA MŠMT(CZ) ED1.1.00/02.0109; GA MŠMT(CZ) LO1309
Institucionální podpora: RVO:68378041
Klíčová slova: human induced pluripotent stem cells * neural precursors * spinal cord injury
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 3.427, rok: 2015

Neural precursors differentiated from induced pluripotent stem cells were grafted into rat spinal cord injury. They survived well and slowly mature into different neuronal phenotypes (GABAergic, serotonergic and motoneurons). In addition, they produced growth factors, stimulating neuronal sprouting. As a result, animals with spinal cord injury significantly improved their motor function. Rats were able to support their body weight and perform stepping, so they scored well in tests requiring movement coordination, such as beam walking or rotarod.
Trvalý link: http://hdl.handle.net/11104/0252351