Frequent Chromatin Rearrangements in Myelodysplastic Syndromes - What Stands Behind?

0435477 - BFÚ 2015 RIV CZ eng J - Článek v odborném periodiku
Pagáčová, Eva - Falk, Martin - Falková, Iva - Lukášová, Emilie - Michalová, K. - Oltová, A. - Raška, I. - Kozubek, Stanislav
Frequent Chromatin Rearrangements in Myelodysplastic Syndromes - What Stands Behind?
Folia Biologica. Roč. 60, č. 2014 (2014), s. 1-7. ISSN 0015-5500. E-ISSN 0015-5500
Grant CEP: GA ČR(CZ) GBP302/12/G157; GA MŠMT(CZ) EE2.3.30.0030
Institucionální podpora: RVO:68081707
Klíčová slova: myelodysplastic syndromes * chromosomal rearrangements * chromosome 5 deletions
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 1.000, rok: 2014

Myelodysplastic syndromes (MDS) represent a clinically and genetically heterogeneous group of clonal haematopoietic diseases characterized by a short survival and high rate of transformation to acute myeloid leukaemia (AML). In spite of this variability, MDS is associated with typical recurrent non-random cytogenetic defects. Chromosomal abnormalities are detected in the malignant bone-marrow cells of approximately 40-80 % of patients with primary or secondary MDS. The most frequent chromosomal rearrangements involve chromosomes 5, 7 and 8. MDS often shows presence of unbalanced chromosomal changes, especially large deletions [del(5), del(7q), del(12p), del(18q), del(20q)] or losses of whole chromosomes (7 and Y). The most typical cytogenetic abnormality is a partial or complete deletion of 5q- that occurs in roughly 30 % of all MDS cases either as the sole abnormality or in combination with other aberrations as a part of frequently complex karyotypes. The mechanisms responsible for the formation of MDS-associated recurrent trans-locations and complex karyotypes are unknown.
Trvalý link: http://hdl.handle.net/11104/0239341