The precision of DCE-MRI using the tissue homogeneity model with continuous formulation of the perfusion parameters

0431811 - ÚPT 2015 RIV US eng J - Článek v odborném periodiku
Bartoš, Michal - Jiřík, Radovan - Kratochvíla, Jiří - Standara, M. - Starčuk jr., Zenon - Torfinn, T.
The precision of DCE-MRI using the tissue homogeneity model with continuous formulation of the perfusion parameters.
Magnetic Resonance Imaging. Roč. 32, č. 5 (2014), s. 505-513. ISSN 0730-725X. E-ISSN 1873-5894
Grant CEP: GA ČR GAP102/12/2380; GA MŠMT ED0017/01/01; GA MŠMT(CZ) LO1212
Institucionální podpora: RVO:67985556 ; RVO:68081731
Klíčová slova: dynamic contrast-enhanced MRI (DCE-MRI) * perfusion * parameter estimation * bolus arrival time
Kód oboru RIV: FS - Lékařská zařízení, přístroje a vybavení
Impakt faktor: 2.090, rok: 2014

The present trend in dynamic contrast-enhanced MRI is to increase the number of estimated perfusion parameters using complex pharmacokinetic models. However, less attention is given to the precision analysis of the parameter estimates. In this paper, the distributed capillary adiabatic tissue homogeneity pharmacokinetic model is extended by the bolus arrival time formulated as a free continuous parameter. With the continuous formulation of all perfusion parameters, it is possible to use standard gradient-based optimization algorithms in the approximation of the-tissue concentration time sequences. This new six-parameter model is investigated by comparing Monte-Carlo simulations with theoretically derived covariance matrices. The covariance-matrix approach is extended from the usual analysis of the primary perfusion parameters of the pharmacokinetic model to the analysis of the perfusion parameters derived from the primary ones. The results indicate that the precision of the estimated perfusion parameters can be described by the covariance matrix for signal-to-noise ratio higher than similar to 20 dB. The application of the new analysis model on a real DCE-MRI data set is also presented.
Trvalý link: http://hdl.handle.net/11104/0236363