Formation of the Tooth-Bone Interface

0425577 - ÚŽFG 2014 RIV US eng J - Článek v odborném periodiku
Fleischmannová, Jana - Matalová, Eva - Sharpe, P. T. - Míšek, Ivan - Radlanski, R.J.
Formation of the Tooth-Bone Interface.
Journal of Dental Research. Roč. 89, č. 2 (2010), s. 108-115. ISSN 0022-0345. E-ISSN 1544-0591
Grant CEP: GA ČR GC524/08/J032; GA AV ČR KJB500450802
Výzkumný záměr: CEZ:AV0Z50450515
Klíčová slova: epithelial root sheath * periodontal ligament cells * 1st branchial arch
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 3.773, rok: 2010

Not only are teeth essential for mastication, but also missing teeth are considered a social handicap due to speech and aesthetic problems, with a resulting high impact on emotional well-being. Several treatment procedures are currently available for tooth replacement with mostly inert prosthetic materials and implants. Natural tooth substitution based on copying the developmental process of tooth formation is particularly challenging and creates a rapidly developing area of molecular dentistry. In any approach, functional interactions among the tooth, the surrounding bone, and the periodontium must be established. Therefore, recent research in craniofacial genetics searches for mechanisms responsible for correct cell and tissue interactions, not only within a specific structure, but also in the context of supporting structures. A tooth crown that is not functionally anchored to roots and bone is useless. This review aims to summarize the developmental and tissue homeostatic aspects of the tooth-bone interface, from the initial patterning toward tooth eruption and lifelong interactions between the tooth and its surrounding alveolar bone.
Trvalý link: http://hdl.handle.net/11104/0231464