Astrocytes and glutamate homeostasis in Alzheimer's disease: a decrease in glutamine synthetase but not in glutamate transporter-1 in the prefrontal cortex.

0397066 - ÚEM 2014 RIV GB eng J - Článek v odborném periodiku
Kulijewicz-Nawrot, Magdaléna - Syková, Eva - Chvátal, Alexandr - Verkhratsky, A. - Rodríguez, J. J.
Astrocytes and glutamate homeostasis in Alzheimer's disease: a decrease in glutamine synthetase but not in glutamate transporter-1 in the prefrontal cortex.
ASN Neuro. Roč. 5, č. 4 (2013), s. 273-282. ISSN 1759-0914. E-ISSN 1759-0914
Grant CEP: GA ČR(CZ) GAP304/11/0184; GA ČR(CZ) GBP304/12/G069; GA ČR GA309/09/1696; GA ČR GA305/08/1384
Institucionální podpora: RVO:68378041
Klíčová slova: Alzheimer's disease * astroglia * GLT-1
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 4.436, rok: 2013

The expression of glutamine synthetase (GS) and glutamate transporter-1 (GLT-1) was analyzed in astrocytes during the progression of AD in a triple-transgenic mouse model. A significant decrease of GS expression was found, which may underlie a gradual decline in the astrocyte-dependent glutamate-glutamine conversion pathway, which in turn may compromise glutamate homoeostasis, leading towards failures in synaptic connectivity with deficient cognition and memory.
Trvalý link: http://hdl.handle.net/11104/0224733