Potentiation of Inhibitory Synaptic Transmission by Extracellular ATP in Rat Suprachiasmatic Nuclei

0392575 - FGÚ 2014 RIV US eng J - Článek v odborném periodiku
Bhattacharya, Anirban - Vávra, Vojtěch - Svobodová, Irena - Bendová, Z. - Vereb, G. - Zemková, Hana
Potentiation of Inhibitory Synaptic Transmission by Extracellular ATP in Rat Suprachiasmatic Nuclei.
Journal of Neuroscience. Roč. 33, č. 18 (2013), s. 8035-8044. ISSN 0270-6474. E-ISSN 1529-2401
Grant CEP: GA AV ČR(CZ) IAA500110910; GA ČR(CZ) GBP304/12/G069; GA MŠMT(CZ) EE2.3.30.0025
Institucionální podpora: RVO:67985823
Klíčová slova: suprachiasmatic nucleus * P2X receptors * P2Y receptors * ATP * GABA * spontaneous inhibitory synaptic currents
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 6.747, rok: 2013

The hypothalamic suprachiasmatic nuclei (SCN), the circadian master clock in mammals, releases ATP in a rhythm. In this study, we examined the expression and function of ATP-gated P2X receptors (P2XRs) in the SCN neurons of rat brain slices. Our data show that ATP activates presynaptic P2X2Rs to regulate inhibitory synaptic transmission within the SCN and that this effect varies between dorsomedial and ventrilateral SCN regions
Trvalý link: http://hdl.handle.net/11104/0221407