Isolation and Cholinesterase Activity of Amaryllidaceae Alkaloids from Nerine bowdenii

0369375 - ÚOCHB 2012 RIV US eng J - Článek v odborném periodiku
Cahlíková, L. - Zavadil, S. - Macáková, K. - Valterová, Irena - Kulhánková, A. - Hošťálková, A. - Kuneš, J. - Opletal, L.
Isolation and Cholinesterase Activity of Amaryllidaceae Alkaloids from Nerine bowdenii.
Natural Product Communications. Roč. 6, č. 12 (2011), s. 1827-1830. ISSN 1934-578X. E-ISSN 1555-9475
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: Nerine bowdenii * GC/MS * belladine * acetylcholinesterase
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 1.242, rok: 2011

Amaryllidaceae species are known as ornamental plants. Some contain galanthamine, an acetylcholinesterase inhibitor. The chemical composition of the alkaloid extract of bulbs of Nerine bowdenii Watson has been analyzed by means of GC/MS. Twenty-two compounds were detected and nineteen of them identified, one of which was belladine. The alkaloid extract showed promising cholinesterase inhibitory activities against human blood acetylcholinesterase (HuAChE; IC50= 87.9.+-.3.5 .mu.g/mL) and human plasma butyrylcholinesterase (HuBuChE; IC50 = 14.8.+-.1.1 .mu.g/mL). Belladine inhibited HuAChE and HuBuChE in a dose-dependent manner with IC50 values of 781.+-.12.5 .mu.M and 284.8±4.2 .mu.M, respectively.
Trvalý link: http://hdl.handle.net/11104/0203455