Počet záznamů: 1
Synthesis and Biological Activity of 22-Deoxo-23-oxa Analogues of Saponin OSW-1
- 1.0368598 - ÚEB 2012 RIV US eng J - Článek v odborném periodiku
Maj, J. - Morzycki, J.W. - Rárová, Lucie - Oklešťková, Jana - Strnad, Miroslav - Wojtkielewicz, A.
Synthesis and Biological Activity of 22-Deoxo-23-oxa Analogues of Saponin OSW-1.
Journal of Medicinal Chemistry. Roč. 54, č. 9 (2011), s. 3298-3305. ISSN 0022-2623. E-ISSN 1520-4804
Grant CEP: GA ČR GA301/08/1649; GA MŠMT ED0007/01/01
Výzkumný záměr: CEZ:AV0Z50380511
Klíčová slova: POTENT ANTITUMOR SAPONIN * CHOLESTANE GLYCOSIDES * ORNITHOGALUM-SAUNDERSIAE * SIDE-CHAINS * AGLYCONE
Kód oboru RIV: EF - Botanika
Impakt faktor: 5.248, rok: 2011
Analogues of the potent cytotoxic saponin OSW-1 were prepared from the readily available steroidal 16 beta,17 alpha,22-triol. The new 22-deoxo-23-oxa analogues of OSW-1 were screened against eight cancer cell lines and normal human fibroblasts. The analogues proved to be slightly less active than OSW-1 but also less toxic to normal cells. They induce concentration- and time-dependent apoptosis of mammalian cancer cells with caspase-3 activation.
Trvalý link: http://hdl.handle.net/11104/0202897
Počet záznamů: 1