Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat

0367313 - FGÚ 2012 RIV US eng J - Článek v odborném periodiku
Morrissey, C. - Grieve, I. - Heinig, M. - Atanur, S. - Petretto, E. - Pravenec, Michal - Hubner, N. - Aitman, T. J.
Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat.
Physiological Genomics. Roč. 43, č. 21 (2011), s. 1207-1218. ISSN 1094-8341. E-ISSN 1531-2267
Grant CEP: GA ČR(CZ) GA301/08/0166; GA MŠMT(CZ) ME10019
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: eQTL * spontaneously hypertensive rat * quantitative trait transcript * sequence variation
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 2.735, rok: 2011

The Spontaneously Hypertensive rat (SHR) is a widely used rodent model of hypertension and metabolic syndrome. By integration of genomic sequence, eQTL and QTT datasets we have identified several genes that are strong positional candidates for pathophysiological traits observed in the SHR strain. These findings provide a basis for the functional testing and ultimate elucidation of the molecular basis of these metabolic and cardiovascular phenotypes
Trvalý link: http://hdl.handle.net/11104/0202044