Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition

0363004 - MBÚ 2012 RIV GB eng J - Článek v odborném periodiku
Kverka, Miloslav - Zákostelská, Zuzana - Klimešová, Klára - Sokol, Dan - Hudcovic, Tomáš - Hrnčíř, Tomáš - Rossmann, Pavel - Mrázek, Jakub - Kopečný, Jan - Verdu, E. - Tlaskalová-Hogenová, Helena
Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition.
Clinical and Experimental Immunology. Roč. 163, č. 2 (2011), s. 250-259. ISSN 0009-9104. E-ISSN 1365-2249
Grant CEP: GA AV ČR KJB500200904; GA AV ČR 1QS500200572; GA AV ČR IAA5020205; GA ČR GD310/08/H077; GA ČR GA303/08/0367; GA ČR GA305/08/0535
Výzkumný záměr: CEZ:AV0Z50200510; CEZ:AV0Z50450515
Klíčová slova: animal models * cytokines/interleukins * DSS colitis
Kód oboru RIV: EE - Mikrobiologie, virologie
Impakt faktor: 3.360, rok: 2011

Commensal bacteria have been shown to modulate the host mucosal immune system. Here, we report that oral treatment of BALB/c mice with components from the commensal, Parabacteroides distasonis, significantly reduces the severity of intestinal inflammation in murine models of acute and chronic colitis induced by dextran sulphate sodium (DSS). The membranous fraction of P. distasonis (mPd) prevented DSS-induced increases in several proinflammatory cytokines, increased mPd-specific serum antibodies and stabilized the intestinal microbial ecology
Trvalý link: http://hdl.handle.net/11104/0199146