Počet záznamů: 1  

Surface-initiated polymerization of 2-hydroxyethyl methacrylate from heterotelechelic oligoperoxide-coated .gamma.-Fe2O3 nanoparticles and their engulfment by mammalian cells

  1. 1.
    0359776 - ÚMCH 2012 RIV US eng J - Článek v odborném periodiku
    Horák, Daniel - Shagotova, Tetiana - Mitina, N. - Trchová, Miroslava - Boiko, N. - Babič, Michal - Stoika, R. - Kovářová, Jana - Hevus, O. - Beneš, Milan J. - Klyuchivska, O. - Holler, Petr - Zaichenko, A.
    Surface-initiated polymerization of 2-hydroxyethyl methacrylate from heterotelechelic oligoperoxide-coated .gamma.-Fe2O3 nanoparticles and their engulfment by mammalian cells.
    Chemistry of Materials. Roč. 23, č. 10 (2011), s. 2637-2649. ISSN 0897-4756. E-ISSN 1520-5002
    Grant CEP: GA ČR GA203/09/1242; GA ČR GAP503/10/0664; GA AV ČR(CZ) KAN401220801
    Výzkumný záměr: CEZ:AV0Z40500505
    Klíčová slova: 2-hydroxyethyl methacrylate * oligoperoxide * surface-initiated polymerization
    Kód oboru RIV: CD - Makromolekulární chemie
    Impakt faktor: 7.286, rok: 2011

    Poly(N-vinylpyrrolidone) (CPA-PVP-IBMB) containing carboxyl from 4-cyanopentanoic acid (CPA) and peroxide from 1-isopropyl-3(4)-[1-(tert-butyl peroxy)-1-methylethyl]benzene (IBMB) chain transfer agent was synthesized as a surface-active macroinitiator for tailored functionalization of γ-Fe2O3. CPA-PVP-IBMB initiated polymerization of 2-hydroxyethyl methacrylate (HEMA) yielding CPA-PVP-block-poly(2-hydroxyethyl methacrylate) (CPA-PVP-block-PHEMA). γ-Fe2O3 obtained by precipitation was modified by CPA-PVP-IBMB and CPA-PVP-block-PHEMA by “grafting-to” using carboxyl groups. “Grafting-from” consisted in polymerization of HEMA initiated from surface of CPA-PVP-IBMB-coated γ-Fe2O3 yielding CPA-PVP-IBMB-coated γ-Fe2O3/PHEMA nanoparticles. Tests with mice leukemia L1210 cells confirmed nontoxicity of CPA-PVP-IBMB-coated γ-Fe2O3/PHEMA. CPA-PVP-IBMB-coated γ-Fe2O3/PHEMA nanoparticles were engulfed by murine macrophages J774.2 and magnetically separated from other cells.
    Trvalý link: http://hdl.handle.net/11104/0197490

     
     
Počet záznamů: 1  

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