Advances in Molecular Mechanisms and Pharmacology of Diabetic Complications

0359624 - FGÚ 2012 RIV IN eng M - Část monografie knihy
Lacinová, Kateřina - Eckhardt, Adam - Pataridis, Statis - Sedláková, Pavla - Mikšík, Ivan
Glycation of proteins – their analysis and physiological aspects.
Advances in Molecular Mechanisms and Pharmacology of Diabetic Complications. Kerala: Transworld research network, 2010 - (Stefek, M.), s. 17-38. ISBN 978-81-7895-499-8
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: proteomics * posttranslational modification * HPLC-MS * CE
Kód oboru RIV: CE - Biochemie

Posttranslational non-enzymatic modifications of proteins (as well as of lipoproteins and glycoproteins) are important protein reactions, which are believed to play an important role in several physiological and pathophysiological processes, such as aging, diabetes mellitus, etc. Non-enzymatic chemical reactions that occur between an oxo-group typically stemming from reducing sugars (or arising from lipid oxidation/peroxidation) and the free amino groups of proteins/peptides lead to the formation of a plethora of still poorly characterized reaction products (the so-called Maillard reaction)
Trvalý link: http://hdl.handle.net/11104/0197375