The first iron(III) complexes with cyclin-dependent kinase inhibitors: Magnetic, spectroscopic (IR, ES+ MS, NMR, Fe-57 Mossbauer), theoretical, and biological activity studies

0359316 - ÚEB 2011 RIV US eng J - Článek v odborném periodiku
Trávníček, Zdeněk - Popa, Igor - Čajan, Michal - Zbořil, R. - Kryštof, Vladimír - Mikulík, J.
The first iron(III) complexes with cyclin-dependent kinase inhibitors: Magnetic, spectroscopic (IR, ES+ MS, NMR, Fe-57 Mossbauer), theoretical, and biological activity studies.
Journal of Inorganic Biochemistry. Roč. 104, č. 4 (2010), s. 405-417. ISSN 0162-0134. E-ISSN 1873-3344
Grant CEP: GA MŠMT 1M0512; GA ČR GA301/08/1649
Výzkumný záměr: CEZ:AV0Z50380511
Klíčová slova: Iron(III) complexes * 57Fe Mössbauer spectroscopy * CDK inhibition
Kód oboru RIV: CA - Anorganická chemie
Impakt faktor: 3.317, rok: 2010

The first FeIII complexes 1–6 with cyclin-dependent kinase (CDK) inhibitors of the type [Fe(Ln)Cl3]•nH2O (n = 0 for 1, 1 for 2, 2 for 3–6; L1–L6 = C2- and phenyl-substituted CDK inhibitors derived from 6-benzylamino-9-isopropylpurine), have been synthesized and characterized by elemental analysis, IR, 57Fe Mössbauer, 1H and 13C NMR, and ES+ mass spectroscopies, conductivity and magnetic susceptibility measurements, and thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The study revealed that the compounds are mononuclear, tetrahedral high-spin (S = 5/2) FeIII complexes with an admixture of an S = 3/2 spin state originating probably from five-coordinated FeIII ions either connecting with a bidentate coordination mode of the CDK inhibitor ligand or relating to the possibility that one crystal water molecule enters the coordination sphere of the central atom in a portion of molecules of the appropriate complex.
Trvalý link: http://hdl.handle.net/11104/0198841