Počet záznamů: 1
What precedes the initial tyrosine phosphorylation of the high affinity IgE receptor in antigen-activated mast cell?
- 1.0353415 - ÚMG 2011 RIV GB eng J - Článek v odborném periodiku
Bugajev, Viktor - Bambousková, Monika - Dráberová, Lubica - Dráber, Petr
What precedes the initial tyrosine phosphorylation of the high affinity IgE receptor in antigen-activated mast cell?
FEBS Letters. Roč. 584, č. 24 (2010), s. 4949-4955. ISSN 0014-5793. E-ISSN 1873-3468
Grant CEP: GA MŠMT 1M0506; GA MŠMT LC545; GA ČR(CZ) GD204/05/H023; GA ČR GA301/09/1826; GA ČR GAP302/10/1759
Výzkumný záměr: CEZ:AV0Z50520514
Klíčová slova: mast cell * cell signaling * plasma membrane
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 3.601, rok: 2010
An interaction of multivalent antigen with its IgE bound to the high-affinity IgE receptor (FcepsilonRI) on the surface of mast cells or basophils initiates a series of signaling events leading to degranulation and release of inflammatory mediators. Earlier studies showed that the first biochemically defined step in this signaling cascade is tyrosine phosphorylation of the FcepsilonRI beta subunit by Src family kinase Lyn. However, the processes affecting this step remained elusive. In this review we critically evaluate three current models (transphosphorylation, lipid raft, and our preferential protein tyrosine kinase–protein tyrosine phosphatase interplay model) substantiating three different mechanisms of FcepsilonRI phosphorylation.
Trvalý link: http://hdl.handle.net/11104/0192670
Počet záznamů: 1