Synthesis and Evaluation of Biological Activity of the Quaternary Ammonium Salts of Lupane-, Oleanane-, and Ursane-Type Acids

0352909 - MBÚ 2011 RIV DE eng J - Článek v odborném periodiku
Biedermann, David - Eignerová, B. - Hajdúch, M. - Sarek, J.
Synthesis and Evaluation of Biological Activity of the Quaternary Ammonium Salts of Lupane-, Oleanane-, and Ursane-Type Acids.
Synthesis. Roč. 42, č. 22 (2010), s. 3839-3848. ISSN 0039-7881. E-ISSN 1437-210X
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: amines * terpenoids * esters
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 2.260, rok: 2010

The anticancer properties of the derivatives of natural pentacyclic triterpenoids have received much attention recently. Here we present the preparation and the evaluation of the anticancer activity of a novel group of derivatives: quaternary ammonium esters. The esters were synthesized by quaternization of the respektive 2-bromoethyl esters of betulinic, dihydrobetulinic, platanic, oleanolic, ursolic, and 3b-acetoxy-21-oxolup-18-en-28-oic acids with common low-molecular-weight tertiary amines, namely trimethylamine, triethylamine, pyridine, and triethanolamine
Trvalý link: http://hdl.handle.net/11104/0192297