Diastereoselective reduction of 1-(4-fluorophenyl)-3(R)-[3-oxo-3-(4-fluorophenyl) -propyl]-4 (S)-(4-hydroxyphenyl)azetidin-2-one to Ezetimibe by the whole cell catalyst Rhodococcus fascians MO22

0352907 - MBÚ 2011 RIV NL eng J - Článek v odborném periodiku
Kyslíková, Eva - Babiak, P. - Marešová, Helena - Palyzová, Andrea - Hajíček, J. - Kyslík, Pavel
Diastereoselective reduction of 1-(4-fluorophenyl)-3(R)-[3-oxo-3-(4-fluorophenyl) -propyl]-4 (S)-(4-hydroxyphenyl)azetidin-2-one to Ezetimibe by the whole cell catalyst Rhodococcus fascians MO22.
Journal of Molecular Catalysis B-Enzymatic. Roč. 67, 3-4 (2010), s. 266-270. ISSN 1381-1177
Grant CEP: GA MŠMT 2B08064
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: Biotransformation * Rhodococcus fascians MO22 * Ezetimibe
Kód oboru RIV: CE - Biochemie
Impakt faktor: 2.330, rok: 2010

Catalytic capability of Rhodococcus fascians MO22 for reduction has been examined with ketone and protected ketone, an intermediate from chemical synthesis of Ezetimibe. Various parameters of the bioreduction have been optimized: the strain converted 94.8 percent of ketone and 63 percent of protected ketone into Ezetimibe with the same de of 99.9 percent. In the later case, two chemical steps are replaced with a single biotransformation
Trvalý link: http://hdl.handle.net/11104/0192295