Beta-arrestins - scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?

0351340 - BFÚ 2011 RIV US eng J - Článek v odborném periodiku
Schulte, G. - Schambony, A. - Bryja, Vítězslav
Beta-arrestins - scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?
British Journal of Pharmacology. Roč. 159, č. 5 (2010), s. 1051-1058. ISSN 0007-1188. E-ISSN 1476-5381
Grant CEP: GA ČR(CZ) GC204/09/J030
Grant ostatní: GA ČR(CZ) GA204/09/0498; GA AV ČR(CZ) KJB501630801
Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Klíčová slova: beta-arrestin * Wnt signaling * dishevelled
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 4.925, rok: 2010

Beta-arrestins were originally identified as negative regulators of G protein-coupled receptor signalling, which can also serve as intracellular scaffolds and signalling intermediates. Here, we summarize the importance of beta-arrestin function for WNT/Frizzled (FZD) signalling. Current findings implicates beta-arrestin as a determinant of WNT signalling specificity, a mediator of WNT/FZD desensitization and a regulator of signalling compartmentation.
Trvalý link: http://hdl.handle.net/11104/0191115